在使用局部基础密度演变模型的COPD中瘤进展风险
Ariel H Curiale1, Carrie Pistenmaa2, Rubén San José Estépar3
1Applied Chest Imaging Laboratory, Department of Radiology and Medicine, Brigham and Women's Hospital, Harvard Medical School, 399 Revolution Drive, Somerville, 02145, MA, USA. acuriale@bwh.harvard.edu.
NPJ digital medicine
|August 28, 2025
概括
在慢性阻塞性肺病 (COPD) 患者中,新的局部肺进展 (LEP) 评分准确预测肺进展. 这种工具有助于早期识别风险,从而改善疾病管理和预后.
科学领域:
- 放射学
- 肺部医学
- 计算生物学
背景情况:
- 肺的进展在COPD是高度可变的,缺乏可靠的预后标志物.
- 治疗选择有限,需要早期检测和干预策略.
- 识别有风险的个体对于减缓疾病进展至关重要.
研究的目的:
- 开发和验证一种用于精确确定瘤进展的局部放射性指标的新方法.
- 引入局部瘤进展 (LEP) 评分作为主体级风险评估工具.
- 评估LEP得分与疾病严重性和临床结果的相关性.
主要方法:
- 利用密度演变的本地化基础模型来识别瘤进展的放射性嵌入.
- 通过聚合局部肺组织激活来计算LEP得分.
- 验证了COPDGene (n=3728) 和ECLIPSE (n=1058) 队列的模型,分析了基线至5年和5年至10年的间隔.
主要成果:
- 该模型在识别肺部瘤进展区域时达到0. 88的AUC.
- LEP风险得分与低衰减区域 (Δ%LAA-950) 的变化有很好的相关性 (r=0. 50 COPDGene,r=0. 40 ECLIPSE).
- 与死亡率和其他COPD结局相关的LEP得分.
结论:
- LEP评分是评估COPD患者肺瘤进展风险的一个有希望的新指标.
- 这种工具可以帮助早期发现和个性化管理策略.
- LEP得分与临床结果的关联凸显了其潜在的临床实用性.
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