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PET/fMRI 显示,减肥手术可以逆转肥胖女性的条状多巴胺功能障碍
Marta Lapo Pais1,2,3, Joana Crisóstomo1,4, Antero Abrunhosa1,2
1Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Coimbra, Portugal.
Communications medicine
|August 28, 2025
概括
减肥手术可以逆转与肥胖相关的大脑多巴胺受体的变化. 这项研究表明多巴胺D2/3受体结合在肥胖症中发生了改变, 这在手术后有所改善, 影响了食欲.
科学领域:
- 神经科学
- 肥胖问题研究
- 医学成像
背景情况:
- 抗肥胖症的治疗通常涉及减肥手术 (BS).
- 中心机制,特别是条纹体中的多巴胺受体功能,被假定是BS成功的关键.
研究的目的:
- 通过BS成功减肥 (WL) 的个体的状区域的中央多巴胺类型2和3受体 (D2/3R) 的研究.
- 探索D2/3R结合,脑部对食物信号的反应和饮食行为之间的关系.
主要方法:
- 在48名女性 (19名BS反应者,12名肥胖者,17名对照者) 中,采用正子发射断层扫描 (PET) 测量D2/3R结合潜力 (BPND).
- 功能磁共振成像 (fMRI) 评估了对食物刺激的脑血液氧化水平依赖性 (BOLD) 反应.
- 分析包括组间比较和D2/3R结合,BOLD反应和饮食行为测量之间的相关性.
主要成果:
- 在肥胖个体和对照个体之间观察到D2/3RBPND的显著差异.
- 与其他群体相比,肥胖个体对食物线索的反应显示出较高的神经激活.
- D2/3R BPND与不适应的饮食行为,食物提示突出,以及肥胖的高热量食物偏好相关. 条纹体中的BOLD反应与D2/3R结合有正相关性.
结论:
- 肥胖与条形多巴胺功能障碍有关,可能会增加食物提示的突出性,并导致强迫性饮食.
- 腹腔外科手术可以有效地扭转肥胖症中观察到的这些分子和功能性条纹性障碍.
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