自适应性Sn-Fe电子对中心在Pt/SnFe2O4中用于抗瘤协同治疗
Meichun Fu1, Zhiyu Shao2,3, Yuan Zhang1
1State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin Provincial International Cooperation Key Laboratory of Advanced Inorganic Solid Functional Materials, College of Chemistry, Jilin University, Changchun 130012, P. R. China.
ACS applied materials & interfaces
|August 28, 2025
概括
研究人员开发了一种新的加铁氧化物材料 (Pt/SFO) 用于增强癌症治疗. 这种材料产生反应性氧物种 (ROS) 用于协同光热,光动力学和化学动力学治疗 (PTT/PDT/CDT).
科学领域:
- 生物材料科学
- 纳米技术
- 癌症治疗
背景情况:
- 光热辅助的抗瘤疗法提供了深层组织透和非侵入性等优势.
- 开发具有增强治疗效果的多功能,生物稳定的光热剂仍然是一个重大挑战.
研究的目的:
- 设计一种电子结构调节的无机光热剂,用于协同抗瘤治疗.
- 研究开发材料的类似酶的活动和反应性氧物种 (ROS) 生成.
主要方法:
- 使用电子结构调节策略,通过将加载到Sn-Fe电子对中心来制造Pt/SFO材料.
- 用实验和理论计算来分析活性中心和ROS产量.
- 评估了光热疗法 (PTT),光动力疗法 (PDT) 和化学动力疗法 (CDT) 的协同疗效.
主要成果:
- Pt/SFO材料表现出类似酶 (CAT),过氧化酶 (POD) 和氧化酶 (OXD) 的活性.
- 与SnFe2O4相比,Pt/SFO-2 (0.9%的Pt负荷) 在近红外激光照射时显示ROS产量增加了9倍.
- 该Pt/SFO-2材料有效地实现了协同PTT,PDT和CDT.
结论:
- 无机光热剂的电子状态调节可以显著提高瘤治疗效率.
- 开发的Pt/SFO材料为调节活性中心电子结构和增强协同癌症治疗提供了一种新的策略.
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