碳水化合物抗原125和心力衰竭的临床结果:系统综述和元分析
Seyed Morteza Pourfaraji1, Fatemeh Ojaghi Shirmard1, Dorsa Salabat1
1Cardiovascular Diseases Research Institute, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
BMC cardiovascular disorders
|August 28, 2025
概括
碳水化合物抗原125 (CA125) 水平升高与心力衰竭患者的死亡率和住院风险增加有关. CA125是评估HF严重程度和治疗反应的有价值的非侵入性工具.
科学领域:
- 心脏病学
- 生物标志物研究
- 临床结果分析
背景情况:
- 碳水化合物抗原125 (CA125) 是心力衰竭的潜在生物标志物.
- 现有研究表明CA125水平与HF预后之间存在关联.
- 需要对各种HF群体进行全面评估.
研究的目的:
- 进行元分析,评估CA125水平与心力衰竭患者的临床结果之间的关联.
- 评估CA125作为HF死亡和住院的预后因素.
- 探索CA125在疾病严重性评估和治疗监测中的有用性.
主要方法:
- 在PubMed,Scopus,Web of Science和Embase的系统文献搜索到2025年4月.
- 使用随机效应和Hartung- Knapp- Sidik- Jonkman模型的29项研究的元分析.
- 在PROSPERO (CRD420251023141) 中注册的研究.
主要成果:
- 较高的CA125水平显著增加了终点事件 (死亡或HF住院) 的风险 (HR 2. 23).
- 这种风险增加在急性 (HR 1.88) 和慢性 (HR 2.52) 心力衰竭子组中一致.
- 在CA125和亲国内生产总值水平之间发现了显著的直接相关性 (r=0.42).
结论:
- CA125是心力衰竭死亡率和住院的重要预后因素.
- CA125可以作为评估疾病严重程度和监测治疗反应的非侵入性,独立于操作者的工具.
- 建议进行进一步的研究,以确定最佳的CA125切断水平来治疗HF,特别是指导尿剂治疗.
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