母亲慢性压力的自发早产影响:来自中国队列研究的证据
Xu Zhou1, Liuxiao Zhang2, Xiang Hong1
1Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, Jiangsu, China.
BMC pregnancy and childbirth
|August 28, 2025
概括
孕产妇的慢性压力,以全静电负荷 (AL) 来衡量,与自发早产 (sPTB) 的风险较高有关. AL的代谢免疫失调类与sPTB风险有显著的关联.
科学领域:
- 生殖健康
- 产妇和胎儿医学
- 压力生理学
背景情况:
- 怀孕期间的慢性压力可能会导致产后不良后果.
- 静态负荷 (AL) 量化了慢性压力的累积生理磨损.
- 需要进一步调查母体AL和自发早产之间的联系.
研究的目的:
- 研究母体全静电负荷 (AL) 与自发早产 (sPTB) 风险之间的关系.
- 确定可能与增加sPTB风险相关的特定AL模式.
主要方法:
- 在中国进行的一项前性队列研究,涉及637名孕妇.
- 在招生时使用10个生物标志物评估静态负荷 (AL).
- 隐性类分析 (LCA) 和逻辑回归用于分析AL模式和sPTB关联.
主要成果:
- 在较高的AL得分和增加的sPTB风险之间发现了显著的正相关性 (OR=1. 28).
- 高AL组的女性患sPTB的风险增加了一倍 (OR=2. 09).
- 一个不同的代谢免疫失调类的AL与较高的sPTB风险显著相关 (OR=2. 60).
结论:
- 怀孕期间的母体静态负荷 (AL) 与自发早产 (sPTB) 的风险增加有关.
- 甲状腺炎的代谢免疫失调模式与sPTB特别相关.
- 评估AL和慢性压力可能有助于识别sPTB高风险怀孕.
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