在动物中,前侧嗅觉核介导并行的膜间通路
Li Wang1,2, Anan Li3, Sen Jin4
1School of Medicine, Jingchu University of Technology, Jingmen, 448000, China.
BMC biology
|August 28, 2025
概括
前侧嗅觉核 (AON) 作为哺乳动物中嗅觉球之间半球间通信的关键枢纽. 它通过不同的刺激性,抑制性和协同内化途径促进气味信息传输.
科学领域:
- 神经科学
- 嗅觉系统研究
- 哺乳动物的大脑电路
背景情况:
- 嗅觉信息的半球间通信对于动物的嗅觉和定位至关重要.
- 哺乳动物半球间嗅觉交流的结构基础尚不清楚.
- 研究嗅觉球泡 (OB) 半球间传播的神经回路是必不可少的.
研究的目的:
- 系统地解剖双边嗅觉灯泡 (OBs) 之间的半球间传输的神经回路.
- 识别OB之间嗅觉信息交换中所涉及的核心结构和途径.
主要方法:
- 用电生理记录来研究神经活动.
- 使用病毒介导的追踪技术来绘制神经连接.
- 参与半球间OB通信的神经回路的系统解剖
主要成果:
- 前侧嗅觉核 (AON) 被确定为OB半球间通信的中心中心.
- 三种不同的途径被描述为:激发性bulbar-inter,抑制性bulbar-inter和双bulbar-co-innervation.
- 突出了AON子区域 (外部和主要部分) 在调解这些途径中的差异性作用,涉及CaMKIIα阳性神经元.
结论:
- 这项研究为半球间嗅觉通讯的神经回路提供了新的解剖洞察力.
- AON分区域的差异性连接有助于理解双边嗅觉信息处理.
- 通过已识别的途径,阐明了嗅觉信息如何在两个OB之间传递.
更多相关视频
10:42A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation
Published on: August 18, 2014
9.1K
06:32Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes
Published on: June 5, 2017
7.2K
相关概念视频
Olfaction
45.1K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
45.1K
Physiology of Smell and Olfactory Pathway
9.5K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
9.5K
Diencephalon: Thalamus and Information Relay
2.2K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
2.2K
Indirect Motor Pathways
1.7K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
1.7K
Olfactory Receptors: Location and Structure
9.6K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.6K
Diencephalon: Hypothalamus and Coordination
2.2K
The hypothalamus is a small yet highly complex and essential brain region that plays a crucial role in regulating various bodily functions. Anatomically, it is located at the base of the brain, just above the brainstem and below the thalamus, forming part of the limbic system.
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
2.2K
