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研究领域生物医学和临床科学瘤学和致癌症预测和预后标志物
高度血清性卵巢癌中的PD-1+NK细胞子集:疾病严重性的指标和联合免疫检查点阻塞的目标

高度血清性卵巢癌中的PD-1+NK细胞子集:疾病严重性的指标和联合免疫检查点阻塞的目标

Marco Greppi ¹, Giovanna Tabellini ², Ornella Patrizi ², Valentina Obino ¹, Matteo Bozzo ³, Mariangela Rutigliani ⁴, Franco Gorlero ^5,6, Martina Di Luca ⁵, Laura Paleari ⁷, Ombretta Melaiu ⁸, Michele Paudice ^9,10, Fabrizio Loiacono ¹¹, Patrizio Castagnola ³, Valerio Gaetano Vellone ^9,12, Pascale André ¹³, Domenico Mavilio ^14,15, Gianluca Ubezio ¹¹, Simona Candiani ^3,11, Camilla Jandus ¹⁶, Lorenzo Moretta ¹⁷, Andrea De Censi ^18,19, Daniel Olive ²⁰, Simona Sivori ^21,22, Eric Vivier ^13,23,24, Fabio Rampinelli ²⁵, Silvia Parolini ², Silvia Pesce ^26,27, Emanuela Marcenaro ^28,29

Marco Greppi ¹, Giovanna Tabellini ², Ornella Patrizi ²

¹Department of Experimental Medicine, University of Genoa, Via G.B. Marsano 10, Genoa, 16132, Italy.
²Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
³Department of Earth, Environment and Life Sciences, University of Genoa, Genoa, Italy.
⁴Department of Laboratory and Service - Histological and Anatomical Pathology Unit, Ente Ospedaliero (E.O.) Galliera Hospital, Genoa, Italy.
⁵Obstetrics and Gynecology Unit, Galliera Hospital, Genoa, 16128, Italy.
⁶DINOGMI Department, University of Genoa, Genoa, 16132, Italy.
⁷Research, Innovation and HTA, A.Li.Sa. Liguria Health Authority, Genoa, 16121, Italy.
⁸Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome, Italy.
⁹Department of Integrated Diagnostic and Surgical Sciences (DISC), University of Genoa, Genoa, 16132, Italy.
¹⁰Pathology University Unit, IRCCS Ospedale Policlinico San Martino, Genoa, 16132, Italy.
¹¹IRCCS Ospedale Policlinico San Martino, Genova, Italy.
¹²Pathology Unit, IRCCS Istituto Giannina Gaslini, Genoa, 16147, Italy.
¹³Innate Pharma Research Laboratories, Innate Pharma, Marseille, France.
¹⁴Unit of Clinical and Experimental Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
¹⁵Department of Medical Biotechnologies and Translational Medicine (BioMeTra), University of Milan, Milan, Italy.
¹⁶Department of Oncology, Ludwig Institute for Cancer Research - University of Lausanne, Lausanne, Switzerland.
¹⁷Bambino Gesù Children's Hospital, Rome, Italy.
¹⁸Division of Medical Oncology, E.O. Galliera Hospital, Genoa, 16128, Italy.
¹⁹Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, E1 4NS, UK.
²⁰Team Immunity and Cancer, CRCM, Aix Marseille Université, CNRS, INSERM, Institut Paoli-Calmettes, Marseille, France.
²¹Department of Experimental Medicine, University of Genoa, Via G.B. Marsano 10, Genoa, 16132, Italy. simona.sivori@unige.it.
²²IRCCS Ospedale Policlinico San Martino, Genova, Italy. simona.sivori@unige.it.
²³Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France.
²⁴APHM, Hôpital de la Timone, Marseille-Immunopôle, Marseille, France.
²⁵Department of Obstetrics and Gynecology, Spedali Civili of Brescia, Brescia, Italy.
²⁶Department of Experimental Medicine, University of Genoa, Via G.B. Marsano 10, Genoa, 16132, Italy. silvia.pesce@unige.it.
²⁷IRCCS Ospedale Policlinico San Martino, Genova, Italy. silvia.pesce@unige.it.
²⁸Department of Experimental Medicine, University of Genoa, Via G.B. Marsano 10, Genoa, 16132, Italy. emanuela.marcenaro@unige.it.
²⁹IRCCS Ospedale Policlinico San Martino, Genova, Italy. emanuela.marcenaro@unige.it.

⁰Department of Experimental Medicine, University of Genoa, Via G.B. Marsano 10, Genoa, 16132, Italy.

Journal of Experimental & Clinical Cancer Research : Cr +

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2025年八月28日

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概括

No abstract available on PubMed

关键词:

免疫检查点免疫疗法自然杀手细胞卵巢癌编程细胞死亡1受体瘤脱离瘤透

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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