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基于横截面和生物信息学的分析:围脂肪厚度作为结石疾病的优异预测指标
Kaifeng Mao1,2, Xiang Xu1, Yifei Zhu1
1Division of Urology, Department of Surgery, The University of Hong Kong- Shenzhen Hospital, Shenzhen City, Guangdong Province, China.
Lipids in health and disease
|August 28, 2025
概括
周围脂肪厚度 (PFT) 比BMI更好地预测结石的发生. 这种与肥胖相关的标志物可能涉及特定的基因和炎症途径.
科学领域:
- 肝脏病学
- 放射学
- 基因组学
- 代谢健康
背景情况:
- 结石病 (KSD) 是一个日益严重的全球健康问题.
- 肥胖是KSD的主要风险因素,与代谢功能障碍和炎症有关.
- 体重指数 (BMI) 是一种常见的肥胖度量,但缺乏内脏脂肪的特异性; 周围脂肪厚度 (PFT) 可能提供更好的预测值.
研究的目的:
- 评估PFT在诊断KSD中的临床实用性.
- 为了阐明将OB与KSD联系在一起的分子机制.
主要方法:
- 对413名患者 (265名KSD,148名对照) 的回顾性分析.
- 使用腹部计算机断层扫描测量PFT.
- 机器学习 (WGCNA,差异表达分析) 对基因表达数据的应用.
- 使用内部和外部数据集开发和验证诊断名录.
- 路径丰富分析
主要成果:
- 与对照组相比,KSD患者的PFT增加,诊断准确度高于BMI.
- PFT被确定为KSD的独立预测因子 (OR=1.20,P<0.001).
- 发现了与OB相关的8个差异表达基因,其中FAM20A和DHRS9是关键的枢纽基因.
- 诊断名录显示了高的预测准确性.
- 丰富分析表明IL-6/JAK/STAT3和TNF-α/NF-κB信号通道与围脂肪-KSD的连接.
结论:
- PFT是KSD风险的实用和可靠标志物,表现优于BMI,适合临床整合.
- 通过炎症途径,FAM20A和DHRS9可能将周脂肪与结石形成联系起来.
- 这些发现为管理与肥胖相关的KSD提供了潜在的治疗目标.
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