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从相关性到因果关系:揭示长非编码RNA在COVID-19病变中的作用

Tianfei Yu^1,2, Yunhan Zhang^3,4, Haolan Zhang^3,4

¹Department of Biotechnology, College of Life Science and Agriculture Forestry, Qiqihar University, Qiqihar, 161006, China. yutianfei2001@163.com.

Virology journal

|August 28, 2025

概括

三种长非编码RNA (lncRNA) 显示了2019年冠状病毒疾病 (COVID-19) 的诊断潜力. 这些lncRNAs,H19,TUG1和CRNDE,可以作为与疾病相关的炎症和纤维化的生物标志物.

科学领域:

分子生物学
生物化学
基因组学

背景情况:

长非编码RNAs (lncRNAs) 越来越多地被认可为它们在疾病发病过程中的作用.
冠状病毒疾病2019 (COVID-19) 涉及复杂的炎症和纤维反应.
确定可靠的生物标志物对COVID-19的诊断和预后至关重要.

研究的目的:

研究COVID-19中三个特定的lncRNAs (H19,TUG1,CRNDE) 的诊断潜力.
探索这些lncRNAs在COVID-19相关炎症和纤维化中的生物学意义.
评估基于 lncRNA 表达的机器学习模型对预测COVID-19 的有用性.

主要方法:

在COVID-19患者中分析H19,TUG1和CRNDE表达水平.
应用机器学习算法来开发COVID-19诊断的预测模型.
与炎症和纤维化相关的临床参数之间的相关性分析.

主要成果:

在COVID-19患者中观察到H19,TUG1和CRNDE的显著差异表达.
机器学习模型展示了基于 lncRNA 资料区分COVID-19 病例的潜力.
这项研究表明这些lncRNA在COVID-19背后的生物过程中发挥了作用.

结论:

H19,TUG1和CRNDE是COVID-19的潜在诊断生物标志物.
这些lncRNAs可能会导致COVID-19的炎症和纤维病理.
需要进一步的研究来验证这些发现并探索治疗含义.

关键词:

COVID-19 的生物标志物诊断潜力炎症和纤维化长非编码RNAs (lncRNAs)机器学习应用

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lncRNA - Long Non-coding RNAs

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siRNA - Small Interfering RNAs

siRNA - Small Interfering RNAs

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MicroRNAs

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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
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