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Updated: Sep 9, 2025

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CDKN2A 缺失与扩散性肺间皮瘤中的免疫荒漠化有关

Federica Torricelli1, Benedetta Donati1, Veronica Manicardi1

  • 1Laboratory of Translational Research, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Journal of experimental & clinical cancer research : CR
|August 28, 2025
PubMed
概括

在扩散性肺间皮瘤 (DPM) 中删除CDKN2A基因会产生免疫抑制性瘤微环境. 这种CDKN2A删除会损害免疫细胞的透和信号传递,这表明它有可能成为免疫检查点抑制剂 (ICI) 治疗反应的预测生物标志物.

关键词:
在CDKN2A扩散性肺间皮瘤遗传改变免疫疗法瘤免疫微环境

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The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
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