使用每日总能耗的时间加权平均值来估计减肥干预期间的能量摄入量
Matthew J Breit1,2, Zhaoxing Pan3, Danielle M Ostendorf1,2,4
1Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Obesity (Silver Spring, Md.)
|August 29, 2025
概括
双标记水 (DLW) 方法使用较少的测量方法准确估计体重减轻期间的能量摄入量. 这种回归建模方法保持了准确性,而不需要早期的每日总能耗 (TDEE) 评估.
科学领域:
- 人类的新陈代谢和营养
- 能源平衡研究
- 重量管理干预措施
背景情况:
- 双重标记水 (DLW) 方法对于估计减肥期间的能量摄入 (EI) 是至关重要的.
- 在早期减肥过程中,每日总能耗 (TDEE) 迅速下降,因此需要进行早期测量以准确估计EI.
- 这项研究解决了长期减肥干预中精细的DLW方法的需求.
研究的目的:
- 开发回归模型以减少测量的时间加权TDEE估计.
- 通过这些模型来评估EI在12个月的减肥干预期间是否保持准确性.
- 根据参考方法验证开发的回归模型的准确性.
主要方法:
- 使用了DRIFT行为减肥试验的数据.
- 在基线和1,6和12个月测量TDEE,体重和组成.
- 开发和验证的回归模型使用两个或三个时间点来估计时间加权的TDEE.
主要成果:
- 回归模型显示出高预测性能 (R2=0.911-0.982).
- 对TDEE的协议限制为121.1-274.5千卡/天,而对%CR则为4.5%-10.3%.
- 与参考模型相比,没有发现显著偏差.
结论:
- 通过回归建模,可以准确估计体重减轻的时间加权TDEE.
- DLW摄入平衡方法保持EI准确度,而不需要早期TDEE测量.
- 这种方法在扩展减肥计划期间简化了能量平衡评估.
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