精神分裂症患者的QT间隔延长:来自莱浦尔的第三级护理中心的横截面研究
Mishthi Malani1, Shrayasi Das2, Anirban Saha2
1Department of Cardiology, †All India Institute of Medical Sciences Raipur, Chhattisgarh, India.
The Indian journal of medical research
|August 29, 2025
概括
抗精神病药物可能会导致QT间隔延长 (QTIP),这是一种危险的心脏病. 这项研究发现稳定的精神分裂症患者中QTIP的患病率较低,但仍建议定期对心脏进行监测.
科学领域:
- 精神病学
- 心脏病学
- 药理学
背景情况:
- 已知抗精神病药物会诱导QT间隔延长 (QTIP).
- QTIP可能导致致命的心律失常.
- 精神分裂症患者通常使用抗精神病药物治疗,
研究的目的:
- 在接受门诊治疗的稳定精神分裂症患者中确定QTIP的患病率.
- 评估抗精神病药物的心脏安全性.
主要方法:
- 纳入了88名稳定的精神分裂症患者 (年龄≥18岁),他们正在接受处方药物治疗.
- 进行了心电图 (ECG),并使用弗里德里西亚和巴塞特的公式计算了纠正的QT间隔.
- 排除标准包括其他精神疾病,物质依赖和同时使用QTIP风险药物.
主要成果:
- 在使用弗里德里西亚配方的参与者中检测到QTIP的比例为3. 4%,在使用巴塞特配方的参与者中检测到QTIP的比例为6. 8%.
- 在QTIP患者和没有QTIP患者之间没有观察到人口统计,人体统计或临床变量的显著差异.
- 在这种稳定的精神分裂症队列中,抗精神病诱导的QTIP的患病率很低.
结论:
- 在稳定的精神分裂症患者中,抗精神病诱导的QTIP似乎很少发生.
- 尽管QTIP的患病率很低,但仍存在危及生命的心脏事件的风险.
- 定期查风险因素和定期心电图监测对于预防心脏不良结果至关重要.
相关概念视频
01:26Psychosis: Goals of Pharmacotherapy
209
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
209
01:28Psychosis and Antipsychotic Drugs: Overview
453
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
453
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
945
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
945
01:17Schizophrenia
217
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
217
01:28Drug Therapy
96
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
96
01:25ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
160
Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
160