相关实验视频

Updated: Sep 9, 2025

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

在唾液腺恶性瘤中癌症干细胞标志物SOX2,OCT4和NANOG的表达特征:系统性审查

Deepti Sharma¹, Shruti Gupta², George Koshy¹

¹Department of Oral and Maxillofacial Pathology, Christian Dental College & Hospital, Ludhiana, India.

The Indian journal of medical research

|August 29, 2025

概括

癌症干细胞标记物SRY-box转录因子2 (SOX2),八粒结合转录因子4 (OCT4) 和Homeobox蛋白NANOG (NANOG) 可能导致唾液腺癌的侵袭性. 它们的联合表达可以指导治疗策略和患者风险分层.

科学领域:

癌症学
分子生物学
干细胞研究

背景情况:

癌症干细胞 (CSCs) 涉及瘤的攻击性,转移,复发和治疗耐药性.
关键的CSC调节剂包括转录因子SOX2,OCT4和NANOG,这些因子对胚胎干细胞多能性至关重要.
唾液腺瘤表现出广泛的行为,从良性到高度攻击性,往往预后不佳,治疗进展有限.

研究的目的:

在唾液腺恶性瘤中系统地审查SOX2,OCT4和NANOG的差异表达和影响.
探索这些转录因子对高风险患者分层的潜力.
确定唾液腺癌的新诊断和预测治疗点.

主要方法:

在PubMed,Scopus,Google Scholar和临床关键数据库中进行了系统的文献搜索.
符合预先定义的资格标准的研究被选中纳入审查.
在选定的十篇文章中进行了数据提取和合成.

主要成果:

十项研究符合本系统性审查的纳入标准.
所有包括的研究都表明SOX2,OCT4和NANOG具有显著的预测功能.
这些标志物也被确定为唾液腺瘤治疗的潜在点.

结论:

转录因子SOX2,OCT4和NANOG可能导致唾液腺恶性瘤的侵袭性和不良预后.
这些转录因子的综合评估可以作为预测瘤行为的有价值标记.
这种结合标记可以为唾液腺癌选择适当的治疗方法.

关键词:

癌症多能性预后情况唾液腺干细胞治疗性的

更多相关视频

In vitro Enrichment of Ovarian Cancer Tumor-initiating Cells

In vitro Enrichment of Ovarian Cancer Tumor-initiating Cells

Published on: February 18, 2015

Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays

Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays

Published on: January 3, 2015

相关概念视频

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...

Somatic to iPS Cell Reprogramming

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...