相关实验视频

Updated: Sep 9, 2025

Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting

Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting

Published on: March 28, 2025

用于体外血液循环的共价有机框架的多孔抗凝材料

Ziru Niu¹, Guanchen Wang¹, Jiayi Yang¹

¹Key Laboratory of Cluster Science, Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, Advanced Research Institute of Multidisciplinary Science, Frontiers Science Center for High Energy Material, Advanced Technology Research Institute (Jinan), School of Interdisciplinary Science, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China.

Advanced healthcare materials

|August 29, 2025

概括

新的多孔共价有机框架 (COF) 为体外电路提供有效的抗凝剂. 这种先进的材料可以防止血凝结和清除脂质,

科学领域:

材料科学
生物医学工程
纳米技术

背景情况:

预防血液凝固对于体外血液循环 (EBC) 治疗至关重要.
由于与凝血因子的不有效相互作用,目前的抗凝血剂具有局限性.
开发新型抗凝剂可以提高安全性,减少对全身抗凝剂的依赖.

研究的目的:

开发基于共价有机框架 (COF) 的高效,血相容的多孔抗凝剂材料.
设计具有量身定制的孔径和功能,以与凝血元件进行精确的相互作用.
在体外和体内评估COF的抗凝效,血液兼容性和双重功能.

主要方法:

有序孔的多孔COF的合成 (1.43.2 nm).
具有特定结合口袋的工程COF与凝血因子的精确相互作用.
通过激活的部分血栓形成时间 (APTT),前血栓时间 (PT) 和血栓时间 (TT) 测定,对抗凝血的体外评估.
在动物模型中对血静功能恢复的体内评估.
模拟体外净化以评估脂质的去除.

主要成果:

COF 显示出显著的抗凝效,延长了APTT,PT 和TT 的1.5至3.6倍.
在试验室中,COF表现出优异的血液兼容性,并且在体内比肝素更快地恢复血静功能.
在模拟净化过程中,COF有效地去除了高达50%的血脂 (TG,TC,LDL),显示出双重抗凝解毒性.

结论:

工程化COF为EBC应用提供有效的抗凝和血液相容性.
由于COF的精确相互作用机制,与传统的抗凝剂策略相比,具有优势.
在抗凝固疗法和血液排毒方面,COF是一种有前途的双重功能材料.

关键词:

共价有机框架抗凝固材料有孔的材料

更多相关视频

An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices

An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices

Published on: August 21, 2020

Microfluidic-based Synthesis of Covalent Organic Frameworks COFs: A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

Microfluidic-based Synthesis of Covalent Organic Frameworks COFs: A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

Published on: July 10, 2017

相关概念视频

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...

Coagulation

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...