在癌症治疗中利用蓝光光生物调节:系统性审查的证据
Bárbara Evelyn Santos de Lima1, Rebeca Barros Nascimento1, Ana Paula Mariano Santos Ginez1
1Medicine-Biophotonics PostGraduate Program, Universidade Nove de Julho/UNINOVE, Sao Paulo, Brazil.
Photochemistry and photobiology
|August 29, 2025
概括
在临床前模型中,蓝光 (BL) 是一种新的癌症疗法,可降低瘤细胞的活力和生长. 需要进一步的研究来标准化临床应用的方案.
科学领域:
- 癌症学
- 光医学
- 生物物理
背景情况:
- 癌症仍然是导致死亡的主要原因,
- 目前的癌症疗法可能会导致瘤的侵袭性和复发性增加,
- 蓝光 (BL) 光生物调制 (PBM) 正成为一种潜在的抗癌方式,但其潜在机制需要阐明.
研究的目的:
- 系统地审查蓝光 (450-470nm) 光生物调节对临床前癌症模型的影响.
- 综合BL抗瘤潜力的发现,包括其对细胞活力,增殖,迁移,入侵,亡和瘤生长的影响.
- 确定当前研究的局限性和改进领域,以促进临床转化.
主要方法:
- 一个符合PRISMA指南的定性系统审查.
- 在2002年至2024年间发表的37项体外和体内研究的分析.
- 在MEDLINE/PubMed,EMBASE和LILACS数据库中进行文献搜索,重点关注临床前癌症模型中的BL PBM.
主要成果:
- 蓝光显示出显著的抗瘤作用,包括细胞活力,增殖,迁移和侵袭的减少.
- BL治疗与癌细胞的活性氧物种 (ROS) 生产增加和亡增强有关.
- 在体内研究表明,BL抑制了瘤生长和转移,从而改善了动物模型的存活率.
结论:
- 根据临床前数据,蓝光光生物调节在癌症治疗中具有相当大的治疗潜力.
- 方法的异质性和对剂量参数的不一致报告阻碍了可复制性和直接比较.
- 标准化方案和进一步的研究对于基于BL的癌症疗法的成功临床转化至关重要.
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