作为多功能分子的洋硫:一个关于最近发现的一种众所周知的蔬菜化合物的故事
Jan Hošek1,2, Daniela Nykodýmová2, Iveta Štefanová3
1Department of Molecular Pharmacy, Faculty of Pharmacy, Masaryk University, Palackého tř. 1946/1, CZ-612 00 Brno, Czech Republic. hosekj@pharm.muni.cz.
Food & function
|August 29, 2025
概括
通过调节PPARγ等途径,洋硫具有显著的抗氧化和潜在的抗糖尿病作用. 虽然这些化合物具有有限的抗炎和抗菌活性,但在慢性疾病治疗中,它们是有前途的营养药.
科学领域:
- 生物化学和分子生物学
- 自然产品化学
- 药理学
背景情况:
- 洋 (Allium cepa L.) 富含生物活性有机硫化合物.
- 最近发现的洋硫具有独特的3,4-二甲基硫环结构.
- 这些化合物被研究为各种生物活动.
研究的目的:
- 综合评估 24 个来自洋的硫样本的抗氧化,抗炎,抗糖尿病和抗菌潜力.
- 探索这些生物活动的作用机制.
主要方法:
- 测量活性氧物种 (ROS) 减少的体外测定.
- 过氧体增殖器激活受体玛 (PPARγ) 路径激活测试.
- 抑制NF-κB信号的测试和细胞毒性评估.
- 对细菌和真菌进行抗菌查,包括Candida albicans.
主要成果:
- 通过降低细胞内ROS,提奥兰具有显著的抗氧化活性,其中一些具有轻微的抗氧化作用.
- 乙乙烯异构体部分激活了PPARγ通路 (22-26%的罗西格利塔反应),表明其具有调节剂的潜力.
- 其他化合物具有最小的抗炎作用.
- 化合物在生理度 (≤10μM) 时是安全的,但在更高的度 (50μM) 时是细胞毒性.
- 有限的抗菌活性被观察到,除了对Candida albicans的适度抗真菌作用.
结论:
- 洋硫是具有重要的抗氧化和潜在的代谢调节性能的多功能分子.
- 它们可以调节氧化应激和炎症,支持它们在营养药中使用.
- 需要对其用于预防和治疗慢性疾病的治疗应用进行进一步研究.
相关概念视频
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