通过因果结构共变网络分析,对精神分裂症患者持续性听觉幻觉的渐进性灰质减少
Xu Shao1,2, Honghong Ren3, Lulin Dai1
1Department of Psychiatry, Zhejiang University School of Medicine, Sir Run Run Shaw Hospital, Zhejiang, China.
Psychological medicine
|August 29, 2025
概括
精神分裂症与听觉幻觉显示出从丘脑开始的渐进性灰质损失. 这项研究绘制了因果关系网络, 揭示了持续性听觉幻觉的脑皮层功能障碍.
科学领域:
- 神经成像
- 精神病学
- 系统神经科学
背景情况:
- 患有听觉幻觉的精神分裂患者表现出明显的形态异常.
- 这一群人中的渐进性灰质缩模式和因果影响传播仍不清楚.
- 这项研究的目的是建立精神分裂症患者持续听觉幻觉的因果结构共变网络.
研究的目的:
- 在精神分裂症患者持续听觉幻觉 (pAH) 中构建因果结构共变网络 (CaSCN).
- 绘制灰色物质体积 (GMV) 变化的因果关系和传播模式.
- 研究GMV缩和听觉幻觉严重程度之间的关系.
主要方法:
- 从90名患有pAH的精神分裂症患者和83名健康对照患者获得T1加权的MRI图像.
- 使用特定阶段的独立t测试来比较群体之间的GMV并确定缩模式和起源.
- 在pAH组中构建了CaSCN,随着幻觉严重程度的增加,绘制了缩起源的因果关系.
主要成果:
- 转基因病毒的减少开始于丘脑,中间额头回旋,罗兰 operculum 和 calcarine,扩展到其他大脑区域,幻觉的严重程度增加.
- 在CaSCN中,泰拉木斯被确定为因果源.
- 过渡节点 (例如,下额头,中后) 将因果信息投射到包括小脑在内的皮层和皮下区域的目标节点.
结论:
- 在精神分裂症和持续的听觉幻觉中,
- 在甲状腺-皮质-小脑电路内发现了因果信息的特定传输模式.
- 研究结果表明,与精神分裂症听觉幻觉相关的脑皮-脑膜电路功能障碍.
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