根据基线三回重度的三回置换结果:TRISCEND II试验
Philipp Lurz1, Rebecca T Hahn2, Susheel Kodali2
1University Medical Centre Mainz, Mainz, Germany.
European heart journal
|August 29, 2025
概括
通过EVOQUE系统进行三管置换 (TTVR) 显著改善了严重三管吐 (TR) 的患者的结果. 在所有重度的TR中观察到好处,在更晚期疾病患者中出现更大改善的趋势.
科学领域:
- 心脏病学
- 干预心脏病学
- 医疗器械
背景情况:
- 三回 (TR) 是一种显著的心脏膜疾病.
- 在TRISCEND II试验中,EVOQUE通过导管进行三门置换 (TTVR) 对单独的药物治疗有好处.
- 本研究分析了根据基线TR严重程度分层的结果.
研究的目的:
- 评估TTVR1年和18个月的临床结果在严重和大规模/ 流性三角吐患者.
- 根据基线TR严重程度,比较TTVR加药疗法与单药疗法.
主要方法:
- 这是一项前性多中心TRISCEND II试验,对400名患者进行了2:1随机分组,分别接受TTVR或对照试验.
- 随机分析将患者分为严重的TR (n=172) 和大规模的TR (n=220) 队列.
- 评估临床结果,生活质量,全因死亡率和心力衰竭住院1个月和18个月.
主要成果:
- 在TTVR后的一年,在重症和大规模/ 暴流性TR组中,超过95%的患者的TR为≤轻度.
- 主要疗效终点是TTVR,不论基线TR的严重程度如何.
- 在18个月后,TTVR的死亡率与对照组相似,但在大规模/暴流TR队列中显著减少了心力衰竭住院.
结论:
- 对于患有≥严重三角吐的患者来说,TTVR具有显著的临床益处.
- 无论基线TR严重程度如何,TR严重程度,功能能力和生活质量都得到改善.
- 在患有更晚期 (大规模/ 暴流) 三腹吐的患者中,可能有更大的益处.
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