亚临床甲状腺功能障碍对复杂化2型糖尿病的病的影响:弗里曼特尔糖尿病研究II期
S A Paul Chubb1, Wendy A Davis1, Timothy M E Davis1,2
1Medical School, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia.
The Journal of clinical endocrinology and metabolism
|August 29, 2025
概括
在2型糖尿病中,持续的亚临床甲状腺功能低下 (SCH) 与白蛋白尿的增加有关,这表明可能存在功能障碍. 早期甲状腺检查可能有助于治疗糖尿病病.
科学领域:
- 内分泌学
- 肝脏病学
- 糖尿病研究
背景情况:
- 亚临床甲状腺功能障碍 (SCH) 在2型糖尿病 (T2DM) 患者内在功能障碍的进展中的作用尚不清楚.
- 了解这种关联对于早期发现和治疗糖尿病病至关重要.
研究的目的:
- 确定4年持续的SCH是否与T2DM患者的功能障碍的发展有关.
- 研究持续的甲状腺功能障碍对糖尿病患者脏健康标志物的影响.
主要方法:
- 一项对城市T2DM患者进行长度观察研究.
- 没有甲状腺功能障碍的参与者 (n=725) 被跟踪了大约4. 3年.
- 根据甲状腺状况对参与者进行了分层分析,分析了估计的膜过率 (eGFR) 和尿中白蛋白:肌素比率 (ACR) 的变化 (高甲状腺症,过渡性SCH/ 甲状腺功能低下,持续性SCH/ 甲状腺功能低下).
主要成果:
- 在任何甲状腺状况组中都没有观察到eGFR的显著变化.
- 患有持续性SCH/ 显性甲状腺功能低下症的参与者显示ACR显著增加 (22. 0 ± 81. 4 mg/ mmol),表明白尿增加.
- 这种ACR的增加并未在甲状腺或过渡性SCH/ 过度甲状腺功能低下组中观察到,这表明持久性SCH与白尿之间存在特定的联系.
结论:
- 在T2DM患者中,持久性SCH与发生性白蛋白尿有关,这是损伤的标志物.
- 这些发现表明,可能需要定期评估T2DM患者的甲状腺功能.
- 甲状腺素替代疗法可能会改善受影响个体的白蛋白尿,因此需要进一步调查.
相关概念视频
Chronic Kidney Disease II: Clinical Manifestations
85
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
85
Diabetes Mellitus: Overview and Type I Subtype
3.2K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.2K
Diabetes Mellitus: Type 2 and Gestational
2.9K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.9K
Chronic Kidney Disease I: Introduction
65
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
65
Pathophysiology of Diabetes
1.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.2K
Diabetes: Symptoms, Diagnosis, and Complications
685
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
685


