里博西基布介导的心血管毒性的血清蛋白质组学:一个探索性病例对照研究
Oraianthi Fiste1, Martina Samiotaki2, Efstathios Manios1
1Department of Clinical Therapeutics & Laboratory, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece.
Proteomics. Clinical applications
|August 29, 2025
概括
利博西基布是一种乳腺癌药物,在不到10%的患者中可能引起心血管毒性. 蛋白质组学确定了可能预测CVT风险的蛋白质,有助于为乳腺癌患者提供个性化的预防策略.
科学领域:
- 癌症学
- 心脏病学
- 蛋白质组学
背景情况:
- 在HR+,HER2转移性乳腺癌中,依赖于环素的4/6酶抑制剂,包括里博西基布,至关重要.
- 与里博西基布相关的心血管毒性 (CVT) 需要进一步描述.
- 了解 ribociclib 诱导的 CVT 的分子机制对于患者的治疗至关重要.
研究的目的:
- 评估与治疗相关的CVT发生率和频谱.
- 通过使用DIA LC-MS/MS,在经历CVT的患者中识别差异表达蛋白质.
- 探索与里博西基布相关的潜在预测生物标志物.
主要方法:
- 这是一项前性单中心研究,涉及成年患者接受里博西基布治疗.
- 对CVT发生率,类型和时间的临床数据收集.
- 血清蛋白质组学分析使用数据独立获取液体染色体-双重质谱 (DIA LC-MS/MS) 在病例与对照中.
主要成果:
- 在27. 2个月的中位随访后,62名参与者中出现了5例 (8. 06%) 的CVT.
- 观察到的CVT包括QTc延长,过时性缺血性发作,深静脉血栓,昏迷和心周溢血.
- 蛋白质组学发现了144种差异表达的蛋白质,免疫反应和新陈代谢等途径受到显著影响.
结论:
- 利博西基布诱导的CVT并非罕见,并且存在超出QTc延长的各种临床表现.
- 蛋白质组分析揭示了潜在的预测生物标志物,用于识别具有高CVT风险的患者.
- 需要在更大的群体中进行进一步的验证,以支持对接受 ribociclib 治疗的乳腺癌患者的个性化心血管预防策略.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
332
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
332
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
291
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
291
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
174
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
174
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
213
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
213
01:33Proteomics
7.9K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.9K
01:21Cancer Survival Analysis
448
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
448