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相关概念视频

Proteomics01:33

Proteomics

7.9K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.9K
Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

6.8K
Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
6.8K

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相关实验视频

Updated: Sep 9, 2025

TMT Sample Preparation for Proteomics Facility Submission and Subsequent Data Analysis
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TMT Sample Preparation for Proteomics Facility Submission and Subsequent Data Analysis

Published on: June 8, 2020

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TDEase:一个开源的数据可视化软件框架,用于通过自上而下的蛋白质定性

Yucheng Liao1, Rui Qian2, Mengting Zhang2

  • 1Center For Machine Learning Research, Peking University, Beijing, China.

Proteomics
|August 29, 2025
PubMed
概括
此摘要是机器生成的。

通过集成的数据处理和交互可视化,TDEase简化了自上而下的蛋白质组学 (TDP) 分析. 这种开源框架为研究人员简化了蛋白形状的表征.

关键词:
数据处理和分析质谱学翻译后修改分析上下蛋白质组学

更多相关视频

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

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Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry
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Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry

Published on: October 24, 2018

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相关实验视频

Last Updated: Sep 9, 2025

TMT Sample Preparation for Proteomics Facility Submission and Subsequent Data Analysis
07:44

TMT Sample Preparation for Proteomics Facility Submission and Subsequent Data Analysis

Published on: June 8, 2020

12.8K
Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

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Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry
10:05

Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry

Published on: October 24, 2018

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科学领域:

  • 蛋白质组学
  • 生物化学
  • 计算生物学

背景情况:

  • 顶向下蛋白质组学 (TDP) 允许完整的蛋白质和蛋白质形式的表征.
  • 现有的TDP软件通常呈现碎片化的工作流程和有限的交互可视化.
  • 非专家用户在当前的TDP工具中面临着的学习曲线.

研究的目的:

  • 推出TDEase,一个整合的分析框架来简化TDP数据的解释.
  • 通过自动化处理和交互式可视化增强TDP数据分析.
  • 专注于针对性的蛋白质形状表征,最初与TopPIC套件集成.

主要方法:

  • TDEase采用了一个模块化架构,用于多进程数据处理和TDVis用于交互可视化.
  • TDPipe通过用户可配置的管道自动化主流TDP算法进行可重复处理.
  • TDVis生成动态仪表板用于多维数据探索,包括特征地图和PTM分析.

主要成果:

  • 使用基因组数据集在蛋白质形状识别和比较分析中展示了TDEase的能力.
  • 确保无和可重复的数据处理.
  • TDVis和TDVisWeb提供交互式,基于网络的可视化,用于增强数据探索.

结论:

  • 对于TDP数据解释的挑战,TDEase提供了一个全面的解决方案.
  • 开源的Python框架有助于未来的新数据类型的开发和整合.
  • TDEase为研究人员提供了高效且易于使用的蛋白形分析工具.