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11种常规和2种非分化瘤中细针吸收的细胞形态特征:与细胞病理学的相关性
Eva Manuela Pena-Burgos1, Pilar López-Ferrer2, Jose Juan Pozo-Kreilinger2
1Pathology Department, Gregorio Marañón General University Hospital, Madrid, Spain.
Diagnostic cytopathology
|August 29, 2025
概括
细针吸收 (FNA) 显示了独特的细胞形态,有助于诊断. 然而,由于重叠的特征,将常规与非差异化瘤区分需要仔细的解释和组织学确认.
科学领域:
- 癌症学
- 细胞病理学
- 外科病理学
背景情况:
- 冠状瘤是一种罕见的恶性瘤,起源于冠状腺残留物.
- 精细针吸收 (FNA) 是深层病变的关键诊断工具.
- 通过细胞学来区分常规和非分化胆瘤亚型是具有挑战性的.
研究的目的:
- 分析FNA样本中的细胞形状特征.
- 将细胞学发现与组织学亚型和免疫组织化学相关联.
- 评估FNA对瘤的诊断效用,包括非分化的变体.
主要方法:
- 来自10名已确诊的瘤患者的13个FNA样本的回顾性审查.
- 细胞形态特征的分析,包括细胞形态,排列和核特征.
- 与组织学亚型 (常规和非分化) 和免疫组织化学概况 (骨质,细胞质,EMA,S100) 的相关性.
主要成果:
- 在所有病例中,状基质中的细胞是常见的.
- 经常观察到突出的核子,双核和核伪含有.
- 在非分化冠状瘤中,细胞异型和形更为明显,但在一些常规类型中也存在;在非分化FNA样本中没有明显的形变化.
结论:
- 根据独特的细胞形态特征,FNA可以提供可靠的冠状瘤诊断.
- 临床和放射性相关性对于准确的采样和解释至关重要,特别是在非分化瘤中.
- 常规和非分化的瘤之间重叠的细胞特征需要谨慎的解释和组织学确认.
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