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Updated: Sep 9, 2025

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

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Published on: December 30, 2016

通过干扰线粒体呼吸来抑制人体FOXP3+调节T细胞功能

Aleksandra Dyczko^1,2, Beatriz F Côrte-Real^1,2,3, Ibrahim Hamad^1,2

¹Laboratory of Translational Immunomodulation, VIB Center for Inflammation Research (IRC), Hasselt University, Diepenbeek, Belgium.

European journal of immunology

|August 29, 2025

概括

在人体调节性T细胞 (Tregs) 中,Teriflunomide损害了线粒体功能,阻碍了它们的抑制活性,并促进了亲炎性表型. 这表明在自身免疫性疾病中对T细胞子集有明显的免疫代谢作用.

科学领域:

免疫学
细胞代谢
药理学

背景情况:

调节性T细胞 (Tregs) 依赖脂肪酸氧化 (FAO) 和氧化化 (OXPHOS) 进行稳定和功能.
线粒体呼吸,特别是电子运输链复合体-III,对于Treg抑制活性至关重要.
多发性硬化症等自身免疫性疾病中的功能障碍Tregs表现出线粒体呼吸功能受损和T助手1 (Th1) 现型.

研究的目的:

研究特里弗隆胺对人类Tregs免疫代谢和功能的影响.
评估特里弗隆米德如何影响Treg线粒体呼吸和表型.

主要方法:

人类Tregs被用特里弗隆米德治疗.
评估了线粒体功能,包括呼吸和复合III活性.
评估了Treg表型和抑制活性.

主要成果:

在人类Tregs中Teriflunomide显著损害了线粒体功能.
这种药物在Tregs中诱导了类似Th1的表型.
治疗Teriflunomide导致有缺陷的Treg抑制活性.

结论:

甲基胺对人类Treg线粒体的功能和稳定性产生负面影响.
通过影响Treg功能,该药物可能促进促炎性T细胞特征.
需要进一步的研究来了解特里弗隆胺对免疫细胞子集的独特影响.

关键词:

自体免疫性免疫新陈代谢多发性硬化症监管T细胞其他:

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