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Updated: Sep 9, 2025

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在长期抗CD20治疗期间具有高Interleukin-1β表达的单细胞群的表型变化

Mie Waede1,2,3,4, Christina Kingo1,2,3, Karina Damsbo1,2,3

  • 1Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.

Annals of neurology
|August 29, 2025
PubMed
概括

在多发性硬化症 (MS) 患者中发现了一种表达高白素-1β (IL1B) 的单细胞子集. 抗CD20疗法增加了这些高IL1B单细胞,这表明在MS的发病和治疗效果中发挥了作用.

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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