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Updated: Sep 9, 2025

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
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Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Published on: April 20, 2021

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节省性B细胞受体突变的广泛背景模型

Kevin Sung1, Mackenzie M Johnson1, Will Dumm1

  • 1Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, United States.

eLife
|August 29, 2025
PubMed
概括

我们开发了一种对体突变 (SHM) 的节约模型,使用核酸背景来更好地分析抗体亲和力成熟. 这些模型比现有方法提供了更好的性能.

关键词:
B细胞受体计算生物学卷积神经网络人类免疫学发生炎症身体突变系统生物学

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