与MASLD进展有关的地中海饮食和相关代谢物特征:前性队列研究
Kai Wang1,2, Shijian Xiang3, Qiangsheng He1,2
1Department of Epidemiology and Biostatistics, Clinical Big Data Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
Hepatology communications
|August 29, 2025
概括
坚持地中海饮食 (MED) 显著降低了与代谢功能失调相关的脂肪性肝病 (MASLD) 患者的肝脏相关事件 (LRE) 和死亡风险. 主要的代谢物如omega-3脂肪酸和白蛋白调解这些保护作用.
科学领域:
- 肝病学
- 营养科学
- 代谢学
背景情况:
- 与代谢功能障碍相关的脂肪酸性肝病 (MASLD) 的治疗通常涉及地中海饮食 (MED).
- 在MASLD患者中,MED粘附及其代谢物特征对肝脏相关事件 (LRE) 和死亡率的具体影响需要进一步澄清.
研究的目的:
- 研究与地中海饮食 (MED) 的坚持,代谢物概况,肝脏相关事件 (LRE) 的风险和MASLD患者的死亡率之间的关联.
- 探讨特定代谢物在MED对MASLD进展的保护作用中的调解作用.
主要方法:
- 在没有基线LRE的47429名MASLD参与者的英国生物库数据的前性分析.
- 使用替代地中海饮食 (aMED) 评分和通过NMR光谱测量代谢生物标志物的地中海饮食 (MED) 坚持的评估.
- 应用考克斯回归,限制立方线和调解分析以确定关联和调解途径.
主要成果:
- 较高的aMED得分与显著降低的LRE风险和全因死亡率相关,表明了剂量反应关系.
- 特定的饮食成分如蔬菜,豆类,坚果,鱼类和适度的酒精摄入量与较低的LRE和死亡风险有关.
- 包括omega-3脂肪酸在内的代谢物,omega-3与总脂肪酸的比率和白蛋白被确定为MED保护作用的重要调解物.
结论:
- 在MASLD患者中,遵守地中海饮食与肝脏相关事件 (LRE) 和死亡率的大幅降低有关.
- 代谢生物标志物,特别是omega-3脂肪酸和小HDL颗粒,在缓解MASLD进展和相关风险方面发挥着至关重要的作用.
更多相关视频
07:03Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
1.0K
11:02Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
643
相关概念视频
01:19MALDI-TOF Mass Spectrometry
5.2K
Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
5.2K
01:26Atherosclerosis III: Management
33
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
33