在血液透析导管中具有双重抗菌和抗血栓功能的转化金属连接物纳米涂层
Chen Liu1, Zhi-Feng Zhou1, Mao-Xia Ran2
1Department of Nephrology, Institute of Kidney Diseases, West China Hospital of Sichuan University, Chengdu 610041, China. zhangling_crrt@163.com.
Journal of materials chemistry. B
|August 29, 2025
概括
一种新型的多多巴胺/肝素/铜 (PDA/Hep/Cu) 纳米复合涂层有效地防止血液透析导管中的感染和血栓. 这种双重作用的涂层提高了末期脏病患者的导管安全性和寿命.
科学领域:
- 生物材料科学
- 纳米技术
- 医疗器械涂层
背景情况:
- 血液透析导管对于末期病患者至关重要,但易受感染和血栓形成的影响.
- 现有的功能性涂层难以同时提供抗菌和抗血栓性质.
研究的目的:
- 为血液透析导管开发一种新型的双功能涂层,具有抗菌和抗血栓功能.
- 通过创建稳定有效的纳米复合材料来解决当前涂层的局限性.
主要方法:
- 使用顺序金属-联体协调,聚合和共价固定,制造聚多巴胺//铜 (PDA/Hep/Cu) 纳米复合材料涂层.
- 通过铜-氨复合和使用碳二胺化工学对合合,将Cu2+纳入PDA框架.
- 在细菌和血栓形成模型中的体外和体内评估,包括猪研究.
主要成果:
- PDA/Hep/Cu涂层对金色葡萄球菌和大肠杆菌具有很高的疗效 (初始99%,持续10天后超过98%).
- 血小板粘附率显著降低 (32. 4%) 和延长部分血小板形成时间 (24 秒).
- 与未涂层的导管相比,体内研究显示细菌定居率降低 (87. 2~91.1%) 和血栓重量 (89%),具有良好的生物相容性.
结论:
- 开发的PDA/Hep/Cu纳米复合材料涂层具有协同抗菌和抗血栓作用.
- 这种双重功能涂层代表了改善血液透析导管安全性和性能的有希望的进步.
- 潜在的应用范围扩展到需要预防感染和血栓的其他接触血液的医疗设备.
相关概念视频
02:51Metal-Ligand Bonds
21.5K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
21.5K
01:24Hemodialysis II: Procedure and Complications
128
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
128
01:22EDTA: Chemistry and Properties
2.2K
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
2.2K