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Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
77
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

323
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
323
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

286
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
286
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

502
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
502
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

874
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
874
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

605
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
605

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Updated: Nov 18, 2025

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients
03:47

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

Published on: October 25, 2024

489

基于儿童-图尔科特-普格评分的抗肺结核疗法:北印度两年后期观察研究

Juned Ahmad1

  • 1Myra Liver Gastro and Endoscopy Centre, Chowk, Lucknow, 226 020, India. ahmadjuned43.jk@gmail.com.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
|August 29, 2025
PubMed
概括

这项研究表明,基于Child-Turcotte-Pugh (CTP) 评分的修改型抗结核治疗在不补偿性肝硬化和结核病患者中耐受良好,近80%的结核病患者得到治疗.

科学领域:

  • 肝病学
  • 传染性疾病
  • 药理学

背景情况:

  • 由于抗结核治疗增加了肝功能衰竭的风险,结核病 (TB) 在非补偿性肝硬化症的治疗更加复杂.
  • 根据CTP得分 (≤7: 2药物,8-10: 1药物,≥11: 0药物) 建议基于儿童- 图尔科特- 普 (CTP) 评分的ATT疗法限制肝毒药物.

研究的目的:

  • 评估基于CTP得分的修改ATT在非补偿性肝硬化和同时发生的结核病患者中的耐受性和有效性.

主要方法:

  • 一项回顾性观察研究分析了2022年4月至2024年4月的电子数据.
  • 修改的ATT疗程是根据CTP得分进行调整的,调整了肝毒药的数量.
  • 强化阶段的治疗方案包括ELA (CTP ≥11),RELA (CTP 8-10),HREL (CTP ≤7). 继续阶段分别为EL,REL和HRE.

主要成果:

  • 在155名缺乏补偿的肝硬化患者中,有21名 (13. 5%) 患有结核病. 所有接受了基于CTP得分的修改ATT.
  • 在密集期内,有4名患者 (19. 1%) 发生肝毒性.
  • 在延续期后,19名患者中有15名 (78. 9%) 获得结核病治愈;4名患者 (21.1%) 因结核病相关原因死亡.

结论:

关键词:
查尔德-图尔科特-普格分数慢性肝脏疾病改性抗结核疗法北印度私人中心结核病

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  • 根据CTP得分进行修改的ATT被不补偿性肝硬化和结核病患者耐受.
  • 这种方法导致结核病治愈率高,接近80%.