素基输送系统:配方,表征和动力评估
Samiah Alhabardi1, Basmah Aldosari1, Gadah Al-Hamoud2
11Department of Pharmaceutics College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Acta pharmaceutica (Zagreb, Croatia)
|August 29, 2025
概括
一种新型的药物输送系统, 是针对抗精神病药 olanzapine 的开发. 基于Span 60的体表现出最佳的特征,这表明了对精神疾病的治疗效果和olanzapine的改善.
科学领域:
- 制药科学
- 药物输送系统
- 纳米技术
背景情况:
- 奥兰扎是治疗精神疾病的重要抗精神病药物.
- 目前的奥兰扎配方可能面临生物可用性和持续释放方面的挑战.
- 体为药物输送应用提供了一个有前途的纳米载体系统.
研究的目的:
- 开发和描述奥兰扎的基于体的输送系统.
- 评估表面活性剂类型和胆固醇比对体特性的影响.
- 评估在体外释放的概况和荷兰zapine-loaded niosomes的稳定性.
主要方法:
- 使用Span表面活性剂 (Span 60, 40, 20) 和胆固醇制备体.
- 配方的特点是颗粒大小,PDI,泽塔电位和封装效率.
- 进行了体外药物释放研究和运动分析 (Korsmeyer- Peppas模型).
主要成果:
- 体大小与表面活性剂HLB相反;Span 60产生了最小的囊泡.
- 最好的配方使用1:1表面活性剂与胆固醇的比率.
- 跨度60的体表现出高封装效率 (81±2. 5%) 和卓越的稳定性.
- 与自由药物相比,所有尼奥索姆配方都表现出持续的奥兰扎释放.
结论:
- 尼奥索姆配方,特别是具有Span 60的配方,是增强奥兰扎输送的有希望的策略.
- 在精神疾病治疗中,这些体可能会改善 olanzapine 的生物可用性和治疗结果.
- 这项研究强调了体在开发先进抗精神病药物输送系统方面的潜力.
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