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Updated: Sep 9, 2025

Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C
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染色体组织中的深度学习:从超分辨率显微镜到临床应用

Mikhail Rotkevich1, Carlotta Viana1, Maria Victoria Neguembor2,3

  • 1Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, 08003, Spain.

Cellular and molecular life sciences : CMLS
|August 29, 2025
PubMed
概括

深度学习通过提高图像分辨率和跟踪色素动态, 彻底改变了三维基因组组织分析. 这种计算方法有助于理解基因表达,并对疾病检测和个性化医疗有新兴的临床应用.

关键词:
人工智能 (AI)染色体结构卷积神经网络 (CNN)光成像技术图像恢复图像细分活细胞分析分子诊断核组织风暴单分子定位显微镜 (SMLM)单颗粒追踪 (SPT)超分辨率显微镜 (SRM)变压器架构

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Super-resolution Fluorescence Microscopy01:37

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Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...
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