在手套胃切除术中注射肉毒素,试点随机对照试验
Grishma Pradhan1, Tyler D Robinson2, Casey Northrup2
1Department of General Surgery, Albany Medical Center, Sixth Floor, 50 New Scotland Avenue, Albany, NY, 12208, USA. grishma.pradhan18@gmail.com.
Surgical endoscopy
|August 29, 2025
概括
在袖子胃切除术 (SG) 期间注射甲状腺毒素 (BP) 是安全的,但不会减少手术后的恶心和吐 (PONV). 未来的研究应该探索手术前内镜治疗的潜在益处.
科学领域:
- 减肥手术
- 胃肠病学
- 外科创新
背景情况:
- 已知注射玻尿酸毒素可以改善食管切除术后的胃通道.
- 在我们的机构中,BP已被作为袖子胃切除术 (SG) 的补充剂来缓解手术后的恶心和吐 (PONV).
研究的目的:
- 作为袖子胃切除术 (SG) 的辅助,评估手术内注射肉毒素 (BP) 的安全性和有效性.
- 评估BP对手术后恶心和吐 (PONV) 的影响.
主要方法:
- 进行了一项前性,双盲随机对照试验 (RCT),比较了带有和没有手术内血压的SG.
- 这项研究在三年时间内在第三级护理中心进行了57次SG手术.
- 主要结局包括手术内BP的安全性及其在治疗PONV中的疗效.
主要成果:
- 在BP和安慰剂组之间没有观察到手术时间或住院时间的显著差异.
- 没有手术期间的并发症,门诊水分,抗药使用率和自我报告的恶心率相似.
- 在安慰剂组中,为胸痛和脱水而重新入院一次30天.
结论:
- 在袖子胃切除术 (SG) 期间注射肉毒素 (BP) 是一种安全的程序.
- 与标准ERAS测量相比,BP没有显著改善术后结果或患者报告的PONV.
- 未来的研究可能会从研究手术前内镜注射肉毒素中获益.
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