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使用新生儿气管吸附物衍生的支气管基底干细胞来模拟呼吸道结膜病毒感染

Caiqi Zhao1, Gaurang M Amonkar1, Paul H Lerou1

  • 1Department of Pediatrics, Division of Newborn Medicine, Massachusetts General Hospital, Boston, MA, USA.

Methods in molecular biology (Clifton, N.J.)
|August 29, 2025
PubMed
概括

这项研究提出了一种从气管吸附物培养婴儿支气管上皮的新方法. 该模型有助于研究婴儿的呼吸道同胞病毒感染.

关键词:
空气-液体接口 (ALI)呼吸道上皮细胞 (AEC)基底干细胞 (BSC)婴儿呼吸道同胞病毒 (RSV)气管吸附剂 (TA)

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The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more...
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