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相关概念视频

Neuroplasticity01:01

Neuroplasticity

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Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

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Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
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Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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Forced Transdifferentiation01:28

Forced Transdifferentiation

2.0K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
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Overview of Muscle Tissues01:25

Overview of Muscle Tissues

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The human body has three types of muscle tissue: skeletal, smooth, and cardiac. Each class has unique properties that enable them to perform specific functions. However, all muscle tissues share certain properties, including elasticity, contractility, and excitability. 
Elasticity
Elasticity is the ability of muscles to stretch and return to their original shape. This property is partly due to elastic fibers — macromolecules that run through the muscles. These fibers are firm and...
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相关实验视频

Updated: Sep 9, 2025

Improved Protocol for Chromatin Immunoprecipitation from Mouse Skeletal Muscle
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Improved Protocol for Chromatin Immunoprecipitation from Mouse Skeletal Muscle

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肌肉可塑性,适应性和表观遗传学

Jonathan Charles Jarvis1

  • 1School of Sport and Exercise Science, Liverpool John Moores University, Liverpool, UK. J.C.Jarvis@ljmu.ac.uk.

Advances in experimental medicine and biology
|August 29, 2025
PubMed
概括

骨肌肉适应其表型以适应活动需求,发展耐力或冲刺特征. 这种显著的细胞可塑性对于运动表现,衰老和代谢健康至关重要.

科学领域:

  • 肌肉生理学
  • 细胞适应
  • 神经肌肉科学

背景情况:

  • 骨肌在成年细胞中表现出显著的表型可塑性.
  • 肌肉纤维适应活动模式的变化,影响基因表达和蛋白质配置.
  • 这种适应受激素信号和机械刺激的影响.

研究的目的:

  • 审查肌肉表型适应的历史证据和实验模型.
  • 突出显示肌肉对改变活动的反应的分子机制.
  • 强调肌肉适应在各种环境中的生理意义.

主要方法:

  • 对肌肉适应的历史实验数据的审查.
  • 来自转录基因组,表观基因组和蛋白质基因组分析的结果的整合.
  • 专注于研究神经肌肉生理学的实验模型的进展.

主要成果:

  • 在成年肌肉细胞中显著的表型适应.
  • 根据活动模式确定"耐力"和"冲刺"的表型.
  • 驱动肌肉适应的多面细胞内机制的阐明.

结论:

  • 肌肉的表型适应是神经肌肉生理学的一个基本方面.
关键词:
运动反应肌肉适应肌肉纤维类型肌肉训练可塑性

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  • 了解这些适应性对于运动训练,管理与年龄相关的肌肉损失以及代谢健康至关重要.
  • 实验模型的进步可以更深入地了解这种细胞可塑性.