在健康和疾病中的乳酸代谢
Daniel A Kane1, Matthew L Goodwin2, L Bruce Gladden3
1Department of Human Kinetics, St. Francis Xavier University, Antigonish, NS, Canada.
Advances in experimental medicine and biology
|August 29, 2025
概括
乳酸盐是关键的代谢物,它将糖分分解与线粒体的能量产生联系起来. 它的水平反映了运动和疾病期间的代谢状态,提供了临床见解.
科学领域:
- 代谢生化学
- 细胞生物能学
- 运动生理学
背景情况:
- 乳酸 (La-) 是将糖解与线粒体呼吸联系起来的中心代谢物.
- 它在全身代谢协调中起着至关重要的作用.
- 乳酸盐运输由单碳酸盐运输体提供便利.
研究的目的:
- 探索乳酸在新陈代谢中的多方面的作用.
- 突出乳酸在运动生理和疾病状态中的重要性.
- 讨论乳酸监测的潜在临床应用.
主要方法:
- 关于乳酸代谢的现有文献的审查.
- 分析乳酸在运动引起的代谢变化中的作用.
- 检查乳酸在癌细胞代谢中的作用 (华堡效应).
主要成果:
- 血液中的乳酸盐水平提供了关于糖分分解和线粒体消耗的见解.
- 运动训练导致乳酸积累的适应.
- 休息时乳酸的升高可能表明代谢功能障碍和疾病.
- 即使有氧,瘤也会增加乳酸的产生 (华堡效应).
结论:
- 乳酸是重要的代谢指标,对运动表现和健康有影响.
- 了解乳酸动态对于诊断和管理代谢障碍至关重要.
- 乳酸的作用扩展到癌细胞信号传递,呈现治疗点.
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