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相关概念视频

The Vestibular System01:29

The Vestibular System

40.2K
The vestibular system is a set of inner ear structures that provide a sense of balance and spatial orientation. This system is comprised of structures within the labyrinth of the inner ear, including the cochlea and two otolith organs—the utricle and saccule. The labyrinth also contains three semicircular canals—superior, posterior, and horizontal—that are oriented on different planes.
40.2K
Equilibrium and Balance01:15

Equilibrium and Balance

5.1K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
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相关实验视频

Updated: Sep 9, 2025

Three Dimensional Vestibular Ocular Reflex Testing Using a Six Degrees of Freedom Motion Platform
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Three Dimensional Vestibular Ocular Reflex Testing Using a Six Degrees of Freedom Motion Platform

Published on: May 23, 2013

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一个综合系统,以视窗眼反射为基础,对小鼠的周围视窗功能进行全面评估

Tong Zhao1, Shijie Xiao1, Wenda Liu2

  • 1Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China.

Journal of the Association for Research in Otolaryngology : JARO
|August 29, 2025
PubMed
概括

这项研究引入了一种新的,无手术的仪器,用于使用前庭眼反射 (VOR) 评估小鼠前庭功能. 该系统量化缺陷并确定特定器官的参与,为标准化前庭检测铺平了道路.

关键词:
综合性小鼠前置功能评估耳部器官半圆形通道视野缺陷小鼠模型视门眼反射 (VORs)

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Behavioral Assessment of the Aging Mouse Vestibular System
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Behavioral Assessment of the Aging Mouse Vestibular System

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Author Spotlight: An Accurate and Quantitative Approach to Study Visual Feature Selectivity of the Optokinetic Reflex in Mice
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Author Spotlight: An Accurate and Quantitative Approach to Study Visual Feature Selectivity of the Optokinetic Reflex in Mice

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相关实验视频

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Author Spotlight: An Accurate and Quantitative Approach to Study Visual Feature Selectivity of the Optokinetic Reflex in Mice
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科学领域:

  • 神经科学
  • 耳鼻喉科
  • 医疗器械

背景情况:

  • 在听觉和前庭功能研究中,可靠的前庭功能测试至关重要.
  • 与使用标准听力脑干响应 (ABR) 设备的听力测试不同,对于前庭测试缺乏广泛采用的仪器.
  • 垂直眼反射 (VOR) 对于诊断垂直眼缺陷和评估小鼠垂直眼功能至关重要,但缺乏系统的评估和可访问的设备.

研究的目的:

  • 开发一个完整的,无手术的仪器系统来评估小鼠前置功能.
  • 建立标准化的眼球旋转校准,使仪器数据一致.
  • 通过各种外围前庭缺陷的小鼠模型来证明新测试设备的有效性和有效性.

主要方法:

  • 开发一个集成的仪表系统,具有角度VOR (aVOR) 和离垂直轴旋转 (OVAR) 模式.
  • 实施标准化的眼睛旋转校准.
  • 评估四种外围前庭缺陷的小鼠模型:注射IDPN,与MET相关的突变 (Cdh23,TMC1),前庭特异性突变 (Zpld1,Otop1) 和单侧前庭损伤 (UVL) 模型.

主要成果:

  • 该系统可进行前庭缺陷的常规量化.
  • 它允许对水平半圆通道和耳骨器官的功能进行单独评估.
  • 该系统可以准确地识别单侧前庭病变模型中的病变侧面.

结论:

  • 开发的系统显示出用于评估小鼠常见前庭缺陷的标准设备的潜力.
  • 这些发现突显了该系统提供前庭功能定量和具体评估的能力.
  • 这项创新解决了前庭研究中可访问和可靠的工具的需求.