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非法类固醇使用和男性和女性的心血管状况
Laust Frisenberg Buhl1,2,3, Louise Lehmann Christensen1,2,3, Rikke Hjortebjerg3,4
1Department of Endocrinology, Odense University Hospital. Odense, Denmark.
类固醇类固醇 (AAS) 在休运动员中的使用与不良的心血管变化有关,包括心脏功能受损和冠状动脉化增加. 长期使用,特别是超过五年,与更严重的化和较差的心室应变有关.
科学领域:
- 心血管医学
- 运动医学
- 内分泌学
背景情况:
- 在休运动员中,非法使用类固醇类固醇 (AAS) 很普遍.
- 关于AAS对心血管的影响的研究有限,特别是在女性使用者身上.
研究的目的:
- 评估使用AAS的丹麦休运动员与非使用者的心血管状况.
- 调查AAS累积暴露与心血管结果之间的关联.
主要方法:
- 涉及丹麦健身中心的活跃使用者,以前使用者和非使用者的横截面研究.
- 心血管评估包括心脏功能和动脉样硬化的成像 (心脏,大腿,冠状动脉斑块).
- 统计分析使用线性和逻辑回归来评估AAS使用与心血管参数之间的关联.
主要成果:
- 两组之间没有发现大腿或动脉斑块或冠状动脉度 (CAC) 的显著差异.
- 在活跃的AAS使用者和非使用者之间发现了冠状动脉非化斑块 (NCP) 的统计学显著差异.
- 较长时间的累积AAS使用与阳性CAC得分和冠状动脉NCP存在的可能性增加有关.
- 使用AAS超过5年与更严重的冠状动脉结相关.
- 累积使用AAS与左心室和右心室的整体纵向应变有关.
结论:
- 在两性休运动员中,累积暴露于类固醇类固醇与不良的心血管发现和心室功能受损有关.
- 暴露超过5年的运动员表现出更严重的冠状动脉化.
- 这些发现强调了在休运动中采取预防措施的必要性.
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