在使用左心室辅助器件的患者中,纤维化4指数预测了与血液相容性相关的不良事件
Takahiro Kurihara1, Eisuke Amiya1, Masaru Hatano1,2
1Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan.
概括
肝纤维化-4 (FIB4) 指数可以预测左心室辅助器件 (LVAD) 患者的血液相容性相关不良事件 (HRAE). 术后FIB4指数较高表明LVAD植入后HRAE的风险增加.
科学领域:
- 心脏病学
- 肝病学
- 生物标志物
背景情况:
- 左心室辅助装置 (LVAD) 的植入对于晚期心力衰竭至关重要.
- 血液相容性相关的不良事件 (HRAE) 是LVAD后的重大并发症.
- 在LVAD患者中需要HRAE预测标记.
研究的目的:
- 在LVAD接受者中研究肝纤维化-4 (FIB4) 指数与HRAE之间的关联.
- 评估FIB4指数作为LVAD植入后临床事件的预后工具.
主要方法:
- 对224名接受LVAD植入的患者进行了回顾性分析.
- 术前和术后FIB4指数的计算.
- 评估FIB4指数与HRAE之间的关联,包括出血,中风和血栓形成.
主要成果:
- 在LVAD植入后,FIB4指数显著下降.
- 术后FIB4指数独立预测复合事件 (所有原因死亡和HRAE).
- 术后FIB4指数> 1. 45与较高的HRAE风险 (p=0. 0038) 和升高的·维莱布兰德因子活性有关.
结论:
- 在LVAD患者中,FIB4指数是HRAE的有价值的预后标记.
- 术后FIB4指数升高表明患者患有不良血液相容性事件的风险增加.
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