侵袭性腺癌 ≤3厘米或固体病理模式的患者的保护因素
Yuanyuan Xu1, Zhongjie Wang1, Yixing Tao1
1Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
概括
地玻璃不透明 (GGO) 成分在具有微毛细细胞/固体图案的侵入性腺癌 (IAC) 中具有保护作用. 这一发现有助于评估复发风险,并指导肺癌患者的治疗.
科学领域:
- 肺部医学
- 胸部手术
- 癌症学
背景情况:
- 侵袭性腺癌 (IAC) 中的微毛细细胞 (MP) 和固体细胞 (S) 病理模式与预后较差有关.
- 在IAC中,地面玻璃不透明 (GGO) 组件被认为是一种潜在的保护因素.
研究的目的:
- 在IAC ≤3cm显示MP/S病态模式时,研究GGO组件的预后意义.
- 评估GGO对特定IAC亚型的复发率和存活率的影响.
主要方法:
- 对547名经过叶片切除术的患者进行了回顾性分析,IAC ≤3厘米.
- 根据MP/S模式和0.5的整合与瘤比率 (CTR) 将IAC分为四组.
- 卡普兰 - 梅尔分析和考克斯回归模型评估整体存活率 (OS) 和无复发存活率 (RFS).
主要成果:
- 与其他组相比,患有MP/ S模式和整合与瘤比率 (CTR) 超过0. 5的患者的5年RFS (67%) 和OS (76%) 显著降低.
- 在CTR结节中,MP/ S的存在没有显著影响RFS或OS.
- 在CTR+结节中,MP/ S与更糟糕的RFS有很强的关联 (P< 0. 001).
结论:
- 在IAC≤3厘米和MP/S模式的患者中,GGO成分可以作为保护因素.
- 这项研究表明,GGO可以完善肺腺癌复发风险评估.
- 这些发现可以为选择的肺癌患者提供辅助治疗策略.
相关概念视频
Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
Factors Affecting the Risk of Infection
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...


