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Updated: Sep 9, 2025

Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool
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Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool

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在imatinib耐药慢性骨髓性白血病患者中的外体miRNA表达概况:试点研究

Raphatphorn Navakanitworakul1, Pirun Saelue2, Tipparat Penglong3

  • 1Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.

PloS one
|August 29, 2025
PubMed
概括

研究人员在慢性髓性白血病 (CML) 患者的外体内发现了特定的微RNA (miRNA). 这些血外体miRNAs,包括miR- 451a和miR- 16-2- 3p,可作为CML中伊马替尼抗性的生物标志物.

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相关概念视频

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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