神经动力学协调层次的可塑性机制,适应Drosophila的昼夜行为
Abhishek Chatterjee1,2, Joydeep De1, Béatrice Martin1
1Institut des Neurosciences Paris-Saclay, Université Paris-Saclay, CNRS, 91400 Saclay, France.
Science advances
|August 29, 2025
概括
果活动的季节性变化通过色素分散因子 (PDF) 信号控制. 降低PDF水平通过调整昼夜神经元及其相互作用来重塑夜间活动模式.
科学领域:
- 时间生物学
- 神经科学
- 动物的行为
背景情况:
- 果的大脑有明确的昼夜振荡器,
- 了解环境变化如何影响这些模式至关重要.
- 神经在日常节律的季节性适应中的作用尚未完全理解.
研究的目的:
- 发现季节性转换机制,
- 阐明环境变化如何影响双模休息活动模式.
- 研究颜色分散因子 (PDF) 在季节性适应中的作用.
主要方法:
- 研究了Drosophila melanogaster的季节性变化.
- 分析了色素分散因子 (PDF) 神经及其受体 (PDFR) 的作用.
- 研究了对糖原合成酶3/SHAGGY和vcDN1p-SIFamide轴的影响.
主要成果:
- 在夏季的条件下, 减少的PDF水平会引发一连串.
- 降低PDF受体 (PDFR) 信号推进晚间输出,并削弱促进午睡的vcDN1p- SIFamide轴.
- 在晚上,vcDN1p神经元会控制背侧神经元.
结论:
- 环境引起的PDFR信号变化会使生物钟网络重新平衡,使每日节律与季节时间保持一致.
- 神经驱动的时钟电路和功能调整可能是季节性适应的保存策略.
- 这项研究揭示了日常行为适应季节性环境变化的机制.
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