在动物研究中逐渐减少药物使用:当前的做法和挑战
Yatong Zhang1,2, Mengrui Chen1,2, Tongtong Jiang1,2
1Department of Pediatrics, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Frontiers in pharmacology
|August 29, 2025
概括
在动物研究中逐渐减少药物的范围审查揭示了各种疾病的不同方法和结果. 未来对动物模型中药物戒断的研究需要标准化方案和评估指标.
科学领域:
- 药理学
- 动物医学
- 临床前研究
背景情况:
- 在动物研究中,药物逐渐减少的方案没有标准化.
- 了解当前的做法对于改善临床前研究至关重要.
研究的目的:
- 综合和总结动物研究中的药物减量方案.
- 在未来的研究中提供标准化逐渐干预的参考.
主要方法:
- 采用了一个范围审查框架.
- 在多个数据库中进行系统搜索,直到2024年5月1日.
- 对疾病类型,药物和逐渐减少的方法进行了提取和分析.
主要成果:
- 包括19项研究,涵盖呼吸道问题,瘤和疼痛等多种疾病.
- 减速方法包括剂量降低,频率降低和间歇剂量.
- 结果包括停用,维持低剂量和替代,报告后逐渐减少.
结论:
- 药物逐渐减少的方法受疾病,持续时间,耐受性和目标的影响.
- 逐渐缩减时间表,方法,里程碑和评估指标的完善是必要的.
- 在动物研究中需要更明确的逐渐缩短时间.
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