通过SelectMDx尿路生物标志物的评估来完善前列腺成像报告的管理
Petrino-Cristian Calinoiu1,2, Daniel Badescu1,2, Ovidiu-Catalin Nechita1,2
1Department of Urology, "Prof. Dr. Th. Burghele" Clinical Hospital, Bucharest, Romania.
Maedica
|August 29, 2025
概括
在PI-RADS3病变的男性中,SelectMDx尿液测试有助于前列腺癌风险分层. 它有助于识别临床意义上的前列腺癌, 可能减少不必要的活检.
科学领域:
- 泌尿外科
- 癌症学
- 生物标志物研究
背景情况:
- 在多参数磁共振成像 (mpMRI) 上诊断PI- RADS 3病变的男性前列腺癌是具有挑战性的.
- 准确的风险分层对于避免不必要的前列腺活检至关重要.
研究的目的:
- 评估SelectMDx尿路生物标记测试的临床效用.
- 评估SelectMDx是否改善PI- RADS3病变的男性临床上显著的前列腺癌风险分层.
- 确定SelectMDx是否可以减少不必要的前列腺活检.
主要方法:
- 在40名PSA≥3ng/ ml和PI- RADS≥3病变的患者中进行前性队列研究.
- 使用SelectMDx测试分析尿样,测量DLX1和HOXC6的mRNA表达.
- 将SelectMDx结果与活检确认的前列腺癌诊断进行比较.
主要成果:
- SelectMDx与活检确认的临床显著性前列腺癌有显著的相关性 (57. 1%阳性与18. 2%阴性,p=0. 031).
- 该测试显示灵敏度为57.14%,特异性为81.82%,预测值为90%.
- SelectMDx在排除恶性瘤和指导选择性活检策略方面表现出潜力.
结论:
- SelectMDx测试是PI-RADS3病变男性风险分层的一个有价值的工具.
- 它可以帮助确定哪些患者可能受益于活检以及哪些患者可以避免.
- 进一步的研究可能会支持将其纳入前列腺癌诊断的临床决策.
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