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慢性自发性疹患者饮食干预的作用:开放式随机对照试验
Aritra Kapat1, Raghunath Murmu2, Satyajit Mandal1
1Department of Paediatric Medicine, Dr. B. C. Roy Post Graduate Institute of Paediatric Sciences, Kolkata, India.
在慢性自发性疹 (CSU) 的儿童中,无伪过敏素的饮食可能有助于减轻症状. 这种饮食干预与药物治疗相结合, 与单独的药物治疗相比,
科学领域:
- 免疫学
- 皮肤病学
- 营养科学
背景情况:
- 慢性自发性疹 (CSU) 是一种导致超过六周的和/或血管的疾病.
- 在食品添加剂和天然物质中发现的伪过敏原可以引发CSU症状,模仿真正的过敏反应.
研究的目的:
- 评估无伪过敏素和低组胺饮食在改善儿科CSU患者的临床结果方面的有效性.
- 评估饮食干预与标准药物治疗的影响.
主要方法:
- 一个开放的随机对照试验, 涉及140名儿科CSU患者.
- 患者被分配到药物治疗 (DR组) 或药物加饮食干预 (DRDI组).
- 在基线,三周和六周使用t测试对组进行了每周活动分数 (UAS7) 的比较.
主要成果:
- 在DR和DRDI组之间没有观察到基线特征的显著差异.
- 在六周后,DRDI组的平均UAS7 (8. 80±4. 27) 与DR组 (10. 19±4. 66) 相比较低.
- 这种症状严重程度的差异没有统计学意义 (p=0. 07).
结论:
- 无伪过敏剂饮食是一种安全且具有成本效益的方法来控制儿童的CSU症状.
- 饮食调整有助于减少慢性自发性疹的临床负担.
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