肠道微生物和牙周炎的饮食指数之间的关联:通过全身炎症进行调解
J H Zhu1, Gehong Sun2, Jia Guo2
1The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Frontiers in nutrition
|August 29, 2025
概括
坚持肠道微生物群的饮食指数 (DI-GM) 与牙周炎风险降低有关. 系统性炎症部分介导了这种关联,表明饮食在预防牙周病中的作用.
科学领域:
- 微生物组研究
- 牙周病学
- 营养科学
背景情况:
- 牙周炎是一种影响牙和支结构的普遍炎症.
- 肠道微生物组合受饮食的影响,可能影响全身健康.
- 系统性炎症与各种慢性疾病有关,包括牙周炎.
研究的目的:
- 检查肠道微生物的饮食指数 (DI-GM) 与牙周炎之间的关联.
- 研究系统性炎症在DI-GM和牙周炎之间潜在的调解作用.
主要方法:
- 2009-2014年国家健康和营养检查调查 (NHANES) 的9022名参与者的横截面分析.
- 由14种饮食成分计算的DI-GM分数;使用CDC/AAP标准定义的牙周炎.
- 进行了多变量逻辑回归,受限立方线和调解分析.
主要成果:
- 较高的DI-GM得分与牙周炎患病率呈反向关联 (每增加1个点的OR:0. 95, p < 0. 001).
- 在DI-GM最高组的个体中,中度 (19%) 和严重 (26%) 牙周炎的几率显著降低.
- 系统性炎症生物标志物,特别是CRP (8. 1%) 和WBC (5. 5%) 部分介导了这种关联.
结论:
- 更多地遵守DI-GM与牙周炎的发病率较低有关.
- 系统性炎症在这种关联中起着部分调解作用.
- 通过饮食调节肠道微生物群是预防牙周疾病的潜在策略.
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