局部和历史的高移动性谱系障碍与hEDS和HSD共享自我报告的症状和并发症
在PubMed上查看摘要
概括
此摘要是机器生成的。局部化HSD/有史以来的HSD患者报告的症状比超移动的埃勒斯-丹洛斯综合征 (hEDS) 患者多. 这些发现表明局部HSD/历史HSD应该被纳入超移动性谱系障碍 (HSD) 的诊断.
科学领域
- 超移动性频谱障碍
- 艾勒斯-丹洛斯综合征
- 临床诊断
背景情况
- 2017年修订的标准旨在将高移动性埃勒斯-丹洛斯综合征 (hEDS) 与其他关节高移动性障碍,称为高移动性谱系障碍 (HSD) 区分开来.
- 该研究调查了局部HSD (L-HSD),历史HSD (H-HSD),hEDS和对照之间的症状差异.
研究的目的
- 为了确定L-HSD/H-HSD患者与对照组,hEDS或HSD患者相比是否表现出不同的症状.
- 评估L-HSD/H-HSD和其他超移动性诊断之间的症状和并发症重叠.
主要方法
- 分析了来自2695名患者的100个自我报告的症状/并发症.
- 患者使用2017年hEDS,HSD,L-HSD/H-HSD标准进行诊断,或被归类为对照组.
主要成果
- 与对照组相比,L-HSD/ H-HSD患者报告的症状显著多 (62%),类似于HSD患者 (58%).
- 在20%的病例中,L-HSD/ H-HSD患者报告的症状比hEDS患者多,包括关节疼痛,疲劳和胃食道反流症 (GERD).
- 与对照组,hEDS和HSD相比,L-HSD/H-HSD的特定症状,如喘息,听力困难,麻醉症和自闭症谱系障碍 (ASD) 显著增加.
结论
- L-HSD/H-HSD与HSD有明显的症状重叠,支持将它们纳入HSD诊断标准.
- 患有HSD (包括L-HSD/ H-HSD) 的患者通常比患有hEDS的患者有更高的症状负担.
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