从杆菌到葡萄糖代谢:DOB值可以作为预测标记吗?
Yu Zhou1, Jie Xu2, Zhigang Huang1
1Department of Gastroenterology, Xuancheng People's Hospital, Affiliated Xuancheng Hospital Wannan Medical College, Xuancheng, Anhui, China.
Frontiers in medicine
|August 29, 2025
概括
杆菌感染与更高的禁食葡萄糖和甘油三水平有关. 13C尿素呼吸测试delta-over- baseline (DOB) 值显示血糖异常的预测值很低,特别是在40岁以下的成年人中.
科学领域:
- 胃肠病学
- 内分泌学
- 公共卫生
背景情况:
- 杆菌感染和葡萄糖代谢异常是常见的慢性疾病贡献者.
- 13C尿素呼吸测试delta超过基线 (DOB) 和禁食血糖 (FBG) 之间的关系尚不清楚.
- 调查DOB在接受健康检查的成年人中对异常FBG的预测能力.
研究的目的:
- 确定H. pylori感染与代谢异常之间的关联.
- 评估DOB对血糖异常的预测值.
主要方法:
- 一项追溯研究,对594名患者进行了13C-尿素呼吸测试 (13C-UBT) 和代谢评估.
- 后勤回归和受限制的立方脊柱模型分析了H. pylori状态,DOB值和代谢参数.
- 接收器操作特征 (ROC) 曲线评估了DOB对异常FBG的诊断性能.
主要成果:
- 与H. pylori阴性个体相比,H. pylori阳性个体的甘油三和FBG水平显著更高.
- H. pylori 感染与不正常的FBG (OR 2. 10) 独立相关,但没有三糖异常.
- 在40岁以下的参与者中,DOB值显示FBG异常的整体区分能力很低 (AUC=0. 590),表现有所改善 (AUC=0. 721).
结论:
- 甲状腺菌感染与快食葡萄糖和甘油三水平的升高有关.
- 13C-UBT DOB值对血糖异常提供了适度的预测,特别是在年轻人 (< 40 岁) 中.
- 需要进行更多的前性多中心研究来验证这些发现并探索机制联系.
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