外部触发的药物输送系统
Huiyang Hu1, Prabhakar Busa1, Yue Zhao2
1Department of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL, 35487, USA.
概括
外部触发的药物输送系统通过光或超声波等外部刺激来控制药物释放,从而提供个性化药物. 这提高了患者的坚持性,并使其具有精确的治疗应用.
科学领域:
- 生物医学工程
- 材料科学
- 纳米技术
- 药物输送系统
背景情况:
- 外部触发的药物输送系统提供精确的药物释放控制.
- 这些系统通过消除针头和提供提醒来提高患者的坚持.
- 个性化医疗是通过患者控制药物释放时间,剂量和持续时间而进步的.
研究的目的:
- 审查外部触发药物输送系统的进展.
- 讨论建设策略和释放机制.
- 探索临床疾病管理中的应用.
主要方法:
- 对响应外部刺激 (光,超声波,磁场,温度) 的药物释放系统研究的审查.
- 对系统构建策略进行讨论.
- 药物释放机制的分析.
主要成果:
- 在对外部刺激做出反应的药物输送系统的开发方面取得了显著进展.
- 不同的刺激如光,超声波,磁场和温度可以用来触发药物释放.
- 这些系统显示出有针对性的药物输送和改善疾病管理的潜力.
结论:
- 外部触发的药物输送系统代表了个性化医学的重大进步.
- 这些系统可以提高患者的坚持性和精确的治疗干预.
- 材料科学,纳米技术,化学和生物学领域的持续研究将推动这一领域的进一步创新.
相关概念视频
Drug Delivery: Miscellaneous Routes
467
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
467
Drug Delivery: Overview
422
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
422
Drug Delivery: Enteral Route
709
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
709
Drug Delivery: Parenteral Route
827
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
827
Non-Oral Extravascular Drug Absorption Routes
294
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
294
Routes of Drug Administration: Overview
7.0K
Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
7.0K


