禁食引起肠道微生物组的突变,影响到1型糖尿病患者
Franziska A Graef1, Bettina Berger2, Lina S Bahr3
1Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.
Frontiers in endocrinology
|August 29, 2025
概括
长时间的禁食显著改变了1型糖尿病患者的肠道微生物组,使其与非糖尿病患者相似. 这些禁食诱导的微生物组变化似乎与疾病类型无关,并可能带来治疗效益.
科学领域:
- 微生物学
- 免疫学
- 代谢科学
背景情况:
- 肠道微生物组与1型糖尿病 (T1D) 的发病有关.
- 营养干预可以调节肠道微生物组,并可以作为补充T1D疗法.
- 长时间的治疗性禁食会影响健康个体的自身免疫疾病和肠道微生物群.
研究的目的:
- 研究长时间禁食对T1D患者肠道微生物组的影响.
- 确定禁食引起的微生物组变化是否具有疾病特异性.
- 探索微生物组变化与禁食后的临床参数之间的相关性.
主要方法:
- 试点研究涉及长期治疗禁食的T1D患者.
- 分析肠道微生物组的组成和结构变化.
- 将T1D患者的微生物组与非糖尿病对照组和多发性硬化症患者进行比较.
- 微生物组变化与临床参数 (胆固醇,血压) 之间的相关性分析.
主要成果:
- 禁食大大改变了T1D肠道微生物组,使其与非糖尿病对照群结合在一起.
- 禁食后的微生物组变化与多发性硬化症患者重叠,与非自身免疫群体一致.
- 禁食诱导的微生物组特征似乎独立于宿主健康状况和疾病类型.
- 在T1D患者中发现了特定细菌家族 (Oscillospiraceae,Lachnospiraceae) 与胆固醇和血压变化之间的显著关联.
结论:
- 由新陈代谢多样化驱动的营养素可用性是塑造肠道微生物组合的关键因素,而不依赖于疾病.
- 禁食会在不同健康状况下产生一致的微生物体特征.
- 需要进一步的研究来确定禁食驱动的微生物组变化与T1D的临床益处之间的因果关系.
更多相关视频
相关概念视频
Diabetes: Symptoms, Diagnosis, and Complications
685
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
685
Diabetes Mellitus: Type 2 and Gestational
2.9K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.9K
Carbohydrate Metabolism
11.7K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.7K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
413
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
413
Metabolic States of the Body: Fasting and Starvation
1.8K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
1.8K
Diabetes Mellitus: Overview and Type I Subtype
3.2K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.2K


