在重新入院的高甘油度患者中对LDL-C目标的追溯研究:风险因素分析
Yuan Ji1,2, Arsheen Chadha2,3, Abhash Krity2,3
1Changzhou Medical Centre, Nanjing Medical University, Changzhou, Jiangsu, China.
Frontiers in endocrinology
|August 29, 2025
概括
低密度脂蛋白胆固醇 (LDL- C) 目标在重新住院的高甘油度血症患者中达到较低. 持续使用降脂疗法和动脉样硬化心血管疾病 (ASCVD) 风险分层改善了LDL- C目标的实现.
科学领域:
- 心脏病学
- 公共卫生
- 药理学
背景情况:
- 低密度脂蛋白胆固醇 (LDL- C) 目标水平持续低至最佳,尽管使用了降脂疗法 (LLT).
- 再住院的高三糖血症患者可能对脂质管理有了更高的认识,但在实现LDL- C目标方面仍然面临挑战.
研究的目的:
- 根据2023年中国指南对再住院的高甘油度患者的脂质管理来评估LDL- C目标的实现.
- 在这个特定的患者群体中确定与LDL- C目标实现相关的风险因素.
主要方法:
- 对再住院的高甘油血症患者的回顾性研究 (2020年7月至2023年5月).
- 用于纵向脂质配置文件的部门特定隐性类型轨迹建模.
- 多变量考克斯回归分析以评估实现目标的风险因素.
主要成果:
- 在8905名患者中,只有27. 1% 患者始终达到LDL- C目标,而25%的患者从未达到目标.
- 持续使用LLT与更高的目标实现有关 (HR:1.23).
- 较高的动脉样硬化心血管疾病 (ASCVD) 风险与达到LDL- C目标的几率增加相关 (HR: 2. 00).
结论:
- 在重新住院的高甘油度患者中,LDL-C的控制仍然不足.
- 持续使用LLT和ASCVD风险分层是改善LDL-C目标的关键.
- 需要加强长期管理和监测,特别是在较低风险的患者中.
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