Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

Search research articles

相关实验视频

Updated: Sep 9, 2025

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

Published on: June 6, 2025

在DCD心脏移植模型中的Ex-Vivo心脏输液机器:最新技术

Chiara Tessari¹, Giovanni Lucertini¹, Mariangela Addonizio¹

¹Cardiac Surgery Unit, Cardio-Thoraco-Vascular and Public Health Department, Padova University Hospital, University of Padua, Padova, Italy.

Transplant international : official journal of the European Society for Organ Transplantation

|August 29, 2025

概括

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Risk Stratification of Adverse Outcomes After Heart Transplantation with the 2022 Definition of Pulmonary Hypertension.

Journal of cardiovascular development and disease·2026

Same author

Use of argatroban as anticoagulation for cardiopulmonary bypass during heart transplantation: A case report.

Journal of cardiothoracic surgery·2026

Same author

Effects of Non-statin Lipid-Lowering Therapies Implementation and Statin Treatment Intensification on Lipid Status in Heart Transplant Recipients: A Single-Centre Retrospective Cohort Study.

High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension·2026

Same author

New frontiers in porcine atrioventricular node decellularization: preserving extracellular matrix architecture for biological scaffolds.

Frontiers in bioengineering and biotechnology·2026

Same author

Comparative Outcomes of Heart Transplant Recipients Aged Below and Above 65 Years: A Single-Center Experience.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2025

Same author

Propensity score analysis of stented versus rapid deployment aortic bioprostheses in patients with small aortic annulus.

Interdisciplinary cardiovascular and thoracic surgery·2025

活体输血机 (EVMP) 通过改善移植质量和结果,有助于循环死亡 (DCD) 心脏移植. EVMP是一个有效的器官保存和运输工具, 减少主要移植功能障碍.

科学领域:

心脏病学
移植医学
器官的保存

背景情况:

循环死亡 (DCD) 之后的捐献心脏移植扩大了捐赠者库,但增加了与缺血相关的心肌损伤 (IRI) 和初级移植功能障碍 (PGD) 的风险.
现实体外机器输液 (EVMP) 正成为减轻这些风险和改善移植评估的策略.

研究的目的:

审查EVMP在DCD心脏移植中的临床作用,结果和未来前景.
分析EVMP对移植质量和患者存活时间的影响.

主要方法:

对DCD心脏捐赠中EVMP的临床前和临床研究进行了全面的审查.
使用器官护理系统 (TransMedics) 进行机器输液的21项临床研究的分析.

主要成果:

临床前研究最初侧重于移植功能评估,最近的研究探索相关疗法.
在DCD心脏移植中使用EVMP的临床结果,包括存活率和排斥发作,与脑死亡后的捐赠结果相似.
在DCD心脏的器官保存和运输方面,EVMP表现出有效性.

结论:

EVMP是DCD心脏移植的一个有价值的工具, 增强器官的保存和运输.

关键词:

在心脏病死亡后的捐赠在体外输血心脏在体外保存心脏心脏移植缺血和再输血损伤

更多相关视频

Pre-clinical Model of Cardiac Donation after Circulatory Death

Pre-clinical Model of Cardiac Donation after Circulatory Death

Published on: August 2, 2019

Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment

Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment

Published on: May 10, 2022

相关实验视频

Last Updated: Sep 9, 2025

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

Published on: June 6, 2025

Pre-clinical Model of Cardiac Donation after Circulatory Death

Pre-clinical Model of Cardiac Donation after Circulatory Death

Published on: August 2, 2019

Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment

Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment

Published on: May 10, 2022

进一步的临床前研究对于降低IRI,使器官恢复成为可能,并尽量减少PGD发生率至关重要.

EVMP提供与传统方法相匹配的结果,支持其在扩大移植选择中的作用.